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[19] Prognosis APAP toxicity is the leading cause for fulminant hepatic failure in the United States, accounting for approximately 39% of all cases

Sonnay et al., 2016, 2017)

While SP3CHO induced comparable bioluminescence levels for FBXO22-WT and the C228A negative control mutant, no induction of bioluminescence and hence no evidence for ternary complex formation could be observed when assaying the C326A mutant (Fig