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proposed that GPX4 serves as a critical regulator of ferroptosis in tumor cells through the inhibition of lipid peroxides formation

58 In addition, Genome-wide CRISPR/Cas9-mediated screen uncovered that cytochrome P450 oxidoreductase promoted ferroptosis across a wide range of lineages and cell-states by peroxidation of membrane polyunsaturated phospholipids

This process promotes the propagation of lipid peroxides, ultimately leading to ferroptosis (Stockwell 2022)

Recent studies have demonstrated that mutation or deletion of the CTR1 gene results in increased cisplatin resistance and reduction of platinum levels (Ishida et al., in vitro (Komatsu et al., 2000), and in various cancers (Nakayama et al., 2002, 2004