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In addition, the severity of headache and RLS was assessed using the Patient Global Impression of Change (PGIC) scale, which is a self-rated seven-point scale with scores ranging from 1 (much better) to 7 (much worse) after CGRP mAb treatment

However, when analyzing the effect of 2DG treatment on clonogenic survival upon irradiation, we observed that 2DG did almost not alter clonogenic survival of TrC1 AKT-WT cells whereas radiosensitivity of TrC1 AKT-E17K cells was slightly decreased, at least at a higher single irradiation dose (8 Gy) ( Figure 3L )

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Our group reported a related biotinylated dimedone analog (DAz-1-biotin, Fig