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doi:10.1016/j.procbio.2005.02.027 Wen S, Zhang T, Tan T (2006) Maximizing production of glutathione by amino acid modulation and high-cell-density fed-batch culture of Saccharomyces cerevisiae

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While this hypoxic-induced increase in glycolytic flux is beneficial for promoting cell growth during hypoxic injury and is therefore adaptive in nature, the mechanisms surrounding this increased glycolytic flux can also be manipulated by cancer cells to promote their growth, even in the presence of adequate oxygen levels, a property of tumor cells known as the Warburg effect [2, 3]

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5.3 Insufficient evidence in the real world and the urgent need for cross-centre standardisation There are still two core obstacles to translating findings on metabolic reprogramming into clinical practice