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28 Excessive ROS production leads to an oxidative inactivation of anti-proteases, alveolar epithelium damage, increased neutrophil retention and increased expression of various inflammatory mediators in the pulmonary microcirculation, aggravating the development of COPD

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These agents can scavenge free radicals and prevent further damage (Jamshidi et al., 2018)

Apoptosis is stimulated by procarbazine, which induces oxidative DNA damage that cannot be repaired by the BER/NER system in Hodgkins lymphoma and brain cancers 96

10.1016/j.mrrev.2003.06.016