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Inflammation, aging, oxidative stress, and hypoxia are the most important mechanisms that can explain the relationship between these pathologies

87 These findings clearly indicate that the stimulation of increases in eNOS expression without simultaneously increasing vascular levels of BH 4 may lead to eNOS uncoupling because of the stoichiometric relationship between endothelial BH 4 and NOS activity

[DOI] [PMC free article] [PubMed] [Google Scholar] 127.Hebbel R.P., Morgan W.T., Eaton J.W., Hedlund B.E

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Neutrophil extracellular traps induce organ damage during experimental and clinical sepsis