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The answer, put simply, is cellular senescence: FOXO4 can interact with p53, which is involved in the regulation of multiple target genes and controls a wide range of cellular processes, including metabolic adaptation, DNA repair, cell cycle arrest, apoptosis, and senescence

Noise exposure Five-week-old mice were exposed to octave-band noise with a frequency range of 816 kHz and sound pressure level (SPL) of 108 dB for 2 h to induce a permanent threshold shift

This reaction produces NADH and acetaldehyde as immediate metabolic intermediates

The pH was brought to 5.3 with 1 M HCl

doi: 10.1016/j.bbadis.2023.166995 51 WangYEshwaranRBeckSCHammesHPWielandTFengY