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Cell (2015) 161:26476

Blood 64(Suppl 1):149a, 1984

Die endogene ALCAR-Produktion nimmt jedoch mit zunehmendem Alter ab

Investigate energy-related toxicity or metabolic rescue mechanisms

The importance of epigenetic mechanisms linked to cell metabolism is further demonstrated by the fact that this bi-directional, NAD + dependent switch of ox-phos to glycolysis, and the switch to T-cell anergy, is mediated by histone modifying sirtuin enzymes at the epigenetic level (261, 262)

PLoS One (2014) 9(7):e102438.10.1371/journal.pone.0102438 73 RytelewskiMTongJGBuensucesoALeongHSMaleki VarekiSFigueredoRet alBRCA2 inhibition enhances cisplatin-mediated alterations in tumor cell proliferation, metabolism, and metastasis