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GPX3 in Digestive System Diseases Digestive system diseases, including inflammatory bowel disease (IBD), diverticulitis, colorectal cancer, and liver diseases, arise primarily through the interplay of genetic and environmental influences

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In summary, hypoxia plays a pivotal role in the metabolic reprogramming, recruitment, activation, and immunosuppressive functions of MDSCs through HIF-1

Overproduction of ROS is likely to be important in enhancing TMZ sensitivity ( Figure 5 ), sorafenib alters TMZ sensitivity via autophagy and the JAK2/STAT3-AIF axis, and this alteration can be reversed by ROS clearance (176)

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High Chlamydia burden promotes tumor necrosis factor-dependent reactive arthritis in SKG mice