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These changes are mild and self-limiting in healthy individuals

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Receptor Binding and Signaling Pathways Both peptides activate the GLP-1 pathway, which lowers hunger cues through effects on the central nervous system, slows gastric emptying to make you feel full for longer, and helps keep glucose levels stable

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Pharmacological inhibition or genetic deletion of components of this pathway has been shown to ameliorate cisplatin nephrotoxicity in preclinical studies [35]

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