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The liver acts as a central immune organ that activates the immune system in response to the circulating antigens (206, 207)

Although anxiety outcomes were borderline (SMD = 0.19, CI: 0.38 to 0.00), they hint at a modest benefit

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It can alleviate the burden on the liver and other detoxification organs, leading to better overall health and improved organ function

Of note, the age-dependent hyperinflammatory status of autophagy- or TBK1-deficient macrophages and DCs in Atg conditional knockout mouse models resembles aging macrophages

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