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Children raised without meat must supplement, or there will be a B12 deficiency even years after they begin eating animal products again

The need for sleep is so powerful that normal sleep will eventually reassert itself

You have likely heard drinking a lot of alcohol may deplete your body of nutrients, and B12 is one of them

Belogolova E, Bauer B, Pompaiah M, Asakura H, Brinkman V, Ertl C, Bartfeld S, Nechitaylo TY, Haas R, Machuy N, Salama N, Churin Y, Meyer TF (2013) Helicobacter pylori outer membrane protein HopQ identified as a novel T4SS-associated virulence factor

Tumors can cause blockages and issues with blood flow

If these develop while taking supplements, they warrant medical assessment to rule out ongoing deficiency or other neurological conditions