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Finally, we previously used an animal experiment to show that RGC loss in Nrf2 knockout mice was much faster after optic nerve damage was induced by crushing the nerve 41

Microvesicle generation from ATP-depleted RBC also correlates with the breakdown of polyphosphoinositides to diacylglycerol on the inner monolayer (Mller et al., 1981)

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Overall, ferroptosis plays a crucial role in HD pathogenesis, and targeting ferroptosis represents a promising therapeutic strategy for HD (Figure 4F)