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Yamamoto K, Soeda Y, Kamisako T, Hosaka H, Fukano M, Sato H et al

October 2007

These data suggest that LCS3as an uncompetitive inhibitorpreferentially binds the disulfide reductases at high concentrations of oxidized substrates, GSSG or DTNB, and does not bind the enzymes in the absence of substrate

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It earned FDA approval, generated billions in revenue, and became the most talked-about weight management compound in modern history

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