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If not rapidly corrected, ischemic end-organ damage occurs, leading to serious morbidity

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An exception is the SSRI fluoxetine, which, because of its long half-life, requires a 5-week washout period or longer (eg, if significant liver impairment is present, up to 23 months is prudent) prior to initiating an MAOI.24,30 Responsiveness to MAOIs in Difficult-to-Treat Depression Evidence of responsiveness to MAOIs in treatment-resistant depression

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