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The major determinants of GSH synthesis are the availability of cysteine, the sulfur amino acid precursor, and the activity of the rate-limiting enzyme,-glutamylcysteine synthetase (GCS)

Cellular senescence: mechanisms and therapeutic potential

10.1089/ars.2015.6407 107 NakajimaS.KitamuraM

482 A Phase II clinical trial (NCT04669808) for the in situ treatment of basal cell carcinoma showed a positive therapeutic effect and achieved 100% complete clearance

Protecting the genome: defence against nucleotide glycation and emerging role of glyoxalase I overexpression in multidrug resistance in cancer chemotherapy