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Serotonin is then converted into N-acetylserotonin and finally into melatonin by the enzymes Serotonin-N-acetyl transferase (SNAT) and hydroxyindole-O-methyltransferase (HIOMT), respectively [142, 143, 147]

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Scheepers L, Jacobsson L, Kern S, Johansson L, Dehlin M, Skoog I

Gould NS, Day BJ: Targeting maladaptive glutathione responses in lung disease

10.1056/NEJMoa1505180 N

In order to further characterize this effect, -Glu-Glu was then tested on cells expressing either of GluN1 and GluN2A or GluN1 and GluN2B NMDAr subunits, bearing in mind that they are the most abundant NMDA receptors found in the hippocampus ( NMDA receptors were expressed first in astroglioma C6 cells