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Mitochondrial Ca 2+ overload sensitises the opening of the mPTP and depolarisation of the mitochondrial inner membrane 9,10,17,51,52,54,55

Injected vitamins are more effective than pill form supplements because they enter directly into the bloodstream, as opposed to first traveling through the digestive tract, then being absorbed into the bloodstream where they lose some of their potency

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Some KA subunits allow Ca 2+ efflux, which in astrocytes can contribute to glutamate vesicular release or activate other Ca 2+ -dependent signaling pathways (see Guerra-Gomes et al., 2013)

Open communication about health status and medication history is essential