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Protein Cell (2021)

Luberto, C

The rising use of monoclonal antibodies for therapeutic purposes is also expected to further propel the European market

The predominantly alpha-helical C-terminal domain is involved with the binding of hydrophobic substrates (such as hydrophobic portions of xenobiotics)

While oxaliplatin induced repetitive action potential discharges in myelinated axons when electrically stimulated at 20C, gene ablation of Na v 1.6 did not evoke such action potential burst upon electric stimulation at the same temperature after oxaliplatin treatment, demonstrating that the induction of cold allodynia by oxaliplatin required Na v 1.6 (Sittl et al., 2012)

However, vitamin supplementation (folic acid, vitamin B 6 and vitamin B 12 ) is generally effective in reducing homocysteine concentrations