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We report the initial visit data as the trial is ongoing

Factors such as muscle strength, flexibility, and neuromuscular control are essential for maintaining joint stability and absorbing mechanical forces

These conditions profoundly impact individuals' health and quality of life, emphasizing the urgent need for effective interventions

Among them, HG-induced inflammatory response is the culprit for the pyroptosis of SCs, and the aberrant activation of NLRP3 inflammatory vesicles is the key link for the induction of pyroptosis and PANoptosis, which suggests that targeting the NLRP3 inflammatory vesicles is a reliable therapeutic pathway

To maintain optimal levels, frequent and costly IV treatments are required, which can be impractical for many individuals

Yoon E, Babar A, Choudhary M et al (2016) Acetaminophen-induced hepatotoxicity: a comprehensive update