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Nevertheless, the homozygote mutant genotype leads to hyperhomocysteinemia only when plasma folate status is low in healthy subjects and in patients with cardiovascular disease, thus subjects with this MTHFR mutation may be sensitive to low folate intake (Christensen et al, 1997

1A, KU-57788 inhibited ATC cell viability in a dose-dependent manner, with IC 50 values of 15.20 M for 8505C, 18.99 M for Hth-7, 12.62 M for CAL-62, 9.71 M for KHM-5M, and 6.95 M for KMH-2, further supporting the potent anti-tumor activity and effective DNA-PKcs inhibition of KU-57788