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We show how the time curve of hepatic cell death depends on the dose of acetaminophen, and how it is affected by the timing of rescue by N-acetylcysteine

USA 105 , 65846589 (2008)

If concomitant use of a CYP3A4 inducer is necessary, follow the patient for reduced efficacy and signs of opioid withdrawal and consider increasing the acetaminophen and codeine phosphate tablets dosage as needed

J Pharmacol Exp Ther 319(1):4452 Qian L, Hong JS and Flood PM (2006b) Role of microglia in inflammation-mediated degeneration of dopaminergic neurons: neuroprotective effect of interleukin 10

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This can lead to the development of innovative treatments that address the root cause of the condition rather than just managing symptoms