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28 In the MONICA/KORA Augsburg surveys, the prevalence of peripheral neuropathy increased from 7.4% in individuals with normal glucose tolerance to 28.0% in those with T2DM as glucose tolerance worsened

Metformin mitigates ischemia-induced damage by maintaining the cellular energy balance and supporting brain repair mechanisms

OGDHc assay OGDHc activity in whole cell lysates was measured using the -Ketoglutarate Dehydrogenase Activity Assay Kit (Colorimetric

doi: 10.1016/j.neuroimage.2011.12.038 16 DuarteJ

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Studies suggest it can influence over 4,000 human genes, essentially signaling older cells to behave like younger, healthier ones