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Indeed, research attention in the last decade has focused significantly on antioxidants targeting the mitochondria, and it appears that the focus is shifting from more traditional antioxidants (see Figure 2)

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Additionally, akin to the response to increased energy intake, nutrient deprivation has been shown as a potent inducer of p53 signalling in various cell types by upstream cues like AMPK signalling, fatty acids, or DNA damage 24,25,26,27

[1] What is the difference between bacteriostatic water and normal saline

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[DOI] [PMC free article] [PubMed] [Google Scholar] 82.Rahman M.A., Rahman M.H., Biswas P., Hossain M.S., Islam R., Hannan M.A., Uddin M.J., Rhim H