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Supporting the translational relevance of our findings, analysis of publicly available transcriptomic datasets (GEO: GSM8328845 and GSM5557972) revealed a consistent trend toward increased MLKL expression in human AAA tissue (Supplementary Fig

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Researchers have demonstrated that amino acid metabolism is related to ferroptosis and that CCH can cause neuronal depolarization to release excess glutamate during the pathogenesis of VD, resulting in excitotoxicity, and high levels of glutamate inhibit the function of System Xc-

NRF-1 is essential for enhancing the transcription of proteins and enzymes involved in various mitochondrial activities, including mitochondrial biogenesis, maintenance of mitochondrial DNA, oxidative phosphorylation, and the regulation of respiratory chain complexes (Choi et al

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