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Metabolic Concerns TMAO (Trimethylamine N-Oxide) Production: Recent concern (2025): Approximately 90% of oral ALC metabolized to TMAO by gut microbiota[21] Plasma TMAO levels: Can reach 50 M after supplementation (1.5 g dose)[21] Cardiovascular risk: Elevated TMAO previously associated with adverse cardiovascular outcomes in observational studies Clinical significance: Uncertain

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One of the elements whose fate is governed by microbial activities is sulfur, an essential constituent of biomass and a crucial player in climate processes

Although GGT expression is highest in the kidneys and intestines but lower in the brain, the central nervous system discrepantly appears to be the most affected by the deficiency

Maintaining antioxidant levels in cells is crucial for protecting our genetic material from the by-products of cell metabolism

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