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for instance, it disupts the integrity and physiological functions of the BBB, which leads to possible undesirable aggregation of blood components, xenobiotics, and exogenous agents in the BBB by inducing CNS injury [163]

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Recent findings reveal that various molecules and pathways, including nuclear receptor coactivator 4, astrocyte-derived lactate, low-density lipoprotein receptor-related protein 1, and cGAS signaling, can influence cerebral IRI progression through unique lactylation mechanisms or by directly regulating overall lactylation levels [113,114,115,116]

Unfortunately, p53 is mutated or depleted in approximately 50% of tumors

References 1 Avsian-KretchmerO.EshdatY.Gueta-DahanY.Ben-HayyimG

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