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Attention Disorders and Executive Function Patients with attention deficit hyperactivity disorder demonstrate altered dopamine signaling that makes them particularly susceptible to motivational disruption from immediate pleasures

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It has been observed that chronic treatment with KI in rats results in the loss of spermatogenesis, decreased activities of enzymes participating in testosterone production, structural and functional changes of the testis, all these abnormalities being accompanied by the increased oxidative stress [186, 187]

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While a causal relationship has not been established, patients with depression or other psychiatric conditions should be monitored for changes in mood or behavior, particularly during the initial weeks of treatment or following dose adjustments

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