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Although small-molecule PHGDH inhibitors effectively suppress tumor proliferation in preclinical models [52, 53], their therapeutic index may be limited by the essential physiological role of de novo serine synthesis in the central nervous system [54]

Research on underutilized or neglected legume fractions (e.g., by-products) remains limited, and the effects of common processing and household food-preparation techniques on polyphenol stability and release are not yet fully characterized

Kidney International 68 , 925937, doi: 10.1111/j.1523-1755.2005.00486.x (2005)

Thus, multi-step isoleucine catabolism enzymes, including the BCKDH complex, are present and active in the nuclei of PDA cells

Neurosurgery: Advancing Brain and Spine Health By Bob Berendsen February 5, 2025 Neurosurgery is a specialized field of medicine focused on the diagnosis and treatment of disorders affecting the spinal cord, nerves, and peripheral nervous system