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Orforglipron belongs to a different chemical series, originally discovered by Chugai Pharmaceutical, and has not shown the liver enzyme elevations or drug-induced liver injury events that affected the Pfizer candidates

This creates an interesting mechanistic distinction

A mild deficiency may cause no symptoms

The investigators interpreted the findings as direct pharmacological validation of the NNMT-knockdown phenotype reported earlier in the Kraus 2014 genetic-validation study