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Engle N

Oxidative stress, amyloid-B Peptide, and altered key molecular pathways in the pathogenesis and progression of alzheimers disease

Oliveira et al., 2022)

Elevated HMGB1 levels have been detected in the blood of patients, where it interacts with receptors such as RAGE and TLR4, forming complexes with IL-1 or LPS to activate proinflammatory signaling pathways (Shimizu et al., 2017)