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Why Metformin Can Leave You Too Tired to Lose Weight If youve been on metformin for years, for insulin resistance, PCOS, or type 2 diabetes, and youre too drained to walk after dinner, cook at home, or stick with any weight-loss plan, a low vitamin B12 level could be part of why

Mutation in mitochondrial ribosomal protein MRPS22 leads to Cornelia de Lange-like phenotype, brain abnormalities and hypertrophic cardiomyopathy

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However, GLAST is mainly expressed in the cerebellum and no brain degeneration is reported in GLAST KO mice 73

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