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In our experience, some patients have a better response at 15mg/kg/day and when the treatment is given three times a day (tid) compared to twice a day (bid)

And if you already have Hashimotos or hypothyroidism, check with your health practitioner before making big increases in your intake of iodine

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Clinical presentation of alcoholic liver disease and non-alcoholic fatty liver disease: Spectrum and diagnosis

Formulation and Dose: The substantial cardiovascular benefits demonstrated in REDUCE-IT are attributed to high-dose (4 g/day), purified eicosapentaenoic acid (icosapent ethyl)

We still see this in todays few remaining hunter-gatherer populations