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doi: 10.1002/jps.22285, PMID: [DOI] [PubMed] [Google Scholar] 229.Wen Z, Yan Z, Hu K, Pang Z, Cheng X, Guo L, et al

The intertwined roles of PERK and IRE1 in angiogenesis, EMT, dormancy, and therapy resistance emphasize why indiscriminate UPR inhibition is unlikely to succeed clinically and why pathway-selective, context-aware strategies are needed