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160,161 In the oncogene-driven Neu and MMTV-PyMT mouse models, the overactivation of the RANK signaling pathway in normal mammary epithelium induces cellular senescence, thereby delaying the onset of breast cancer but promoting subsequent metastatic invasion

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Recently, it has also been demonstrated that abnormal regulation of GSTZ1-1 expression in cancer cells may influence DCA metabolism, and consequently lead to an altered therapeutic response 84

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Further regulation of gastrulation is achieved when Wnt uses ROR2 along with the CDC42 and JNK pathway to regulate the expression of PAPC

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