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Complementing these clinical advances, diroximel fumarate, with brand name as Vumerity, a structurally optimized derivative of DMF, has been approved for the management of MS [28]

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A study demonstrated that curcumin upregulates this miRNA, resulting in the suppression of PI3K/Akt signalling and a subsequent reduction in the proliferation rate of A549 cells (Jin et al., 2015)

This could be attributed to the fact that the assessment of PLGA-based nanoparticles for PD treatment focused mainly on dopamine levels and short-term symptomatic improvements 117,121,124,126