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Finally, an imbalance in GSSG:GSH ratio induces ER stress and dependency on the ER-associated degradation (ERAD) pathway, driven by a shift in protein disulfide isomerases (PDIs) toward their oxidized forms

Correlation of the Wnt signaling pathway with ASD pathophysiology has also been demonstrated by the finding that the Wnt pathway is regulated by chromodomain-helicase-DNA-binding protein 8 (CHD8), and de novo mutations of CHD8 are increasingly found in ASD individuals [183,184,185]