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In a study analyzing the expression of mouse IGFBPs at different ages [104], IGFBP4 and -5 were found to be increased with age, whereas IGFBP3 and -6 were regulated differently between males and females: IGFBP-3 decreased with age in males but increased in females, while IGFBP-6 decreased with age in females and remained unchanged in males

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Species-specific factors profoundly influence both efficacy and safety profiles across all four peptide components

Hoeflich A, Wu M, Mohan S, Fll J, Wanke R, Froehlich T, Arnold GJ, Lahm H et al (1999) Overexpression of insulin-like growth factor-binding protein-2 in transgenic mice reduces postnatal body weight gain