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Keywords: Antioxidants, cerebral circulation, endothelial dysfunction, NRF2, oxidant stress, Protandim, reactive oxygen species, resistance arteries, salt, sodium, superoxide dismutase, vascular dysfunction, vasodilation INTRODUCTION Although oxidant stress has been implicated experimentally in a variety of human diseases including cardiovascular pathologies, clinical trials investigating oral antioxidant therapies in the prevention of morbidity and mortality have shown little-to-no benefit with antioxidant supplementation

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Interestingly, ACSS2 expression promoted myelomatous tumorigenesis through stabilization of IRF4, an oncogenic protein controlling a wide variety of genes that are key for cellular growth, survival and metabolic processes [75, 76]

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Chiral derivatization and LCMS analysis of amino acids Chiral derivatization assay Immunoprecipitated peptides were digested into amino acids by leucine aminopeptidase (3.6 l, 0.5 U) in 100 l of buffer (5 mM MgCl 2 , 100 mM NH 4 HCO 3 , pH 7.9) at 37 C for 24 h

TABLE 1 Mitochondria-targeted therapeutics