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Simulations suggested that this microsphere formulation could allow for once-monthly human dosing while maintaining effective drug levels, potentially reducing adverse side effects

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Relationship of iron metabolism and short-term cuprizone treatment of C57BL/6 Mice

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Although mitochondrial dysfunction and increased oxidative stress [54, 56, 89,90,91,92,93,94,95] is evident across studies [37, 65,66,67,68,69], direct investigation into specific parameters have reported contradictory results, impacting the development of a diagnostic test [37]

This delivery method allows the peptide to reach cartilage tissue at effective concentrations while minimizing systemic exposure