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Vitamin B5 (Pantothenic Acid) is a component of coenzyme A

While Abs have an excellent safety profile compared with other therapeutic classes, there are cases where their specific targeting go awry

Recurrent or prolonged seizures have long been known to permanently alter neuronal circuitry and to cause excitotoxic injury and aberrant inflammation

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Consistent with decreased RNR activity, treatment of Control cells with nutlin-3 or MI-773 decreased levels of dAMP, a metabolite downstream of RNR (Fig 3E)