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In conclusion, as shown in Fig S1, the activation of eNOS by BPC 157 is mediated through multiple regulation processes including the promotion of VEGFR2 activation and endocytosis, the activation of positive regulator AKT, the reduction of the interaction of negative regulator Cav-1 with eNOS

Research into intranasal VIP has examined parameters such as VIP stability in nasal wash solutions, formulation pH, osmolarity, and the use of lauroylcarnitine as an absorption enhancer

The addition of adamantylated glycine groups to CNTF small peptides, which resulted in pentamer named Peptide 021, was also found to significantly increase BBB permeability [58]