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Depending on the specific bleeding problem, symptoms can include abnormal bruising, prolonged bleeding from cuts, bleeding in the skin, bleeding into the joints or gastrointestinal tract (causing black, tarry stools or bright red blood in the stool), or gum bleeding even with gentle flossing or brushing

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Overdose : It is possible to overdose on B vitamins, although this is rare

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Current guidelines recommend anti-CD38 antibody-based triplet combinations for relapsed/refractory disease after one to three prior lines of therapy, incorporating previously unused agents for lenalidomide- or bortezomib-refractory disease