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However, despite these limitations, the results collectively emphasize the crucial role of Nrf2-mediated oxidative stress in regulating the pathogenesis of RA, providing new insights for the clinical treatment of this condition (Fig

Drug tolerance for the low-concentration PC was established to be a free drug concentration in blood of approximately 4583.8 ng/mL for monkeys and 6610.4 ng/mL for rats

The maladaptive changes in the dopaminergic system further emphasize the role of neurotransmitter receptor remodeling in the development of mood disorders

Beyond the extensively studied NRF2 pathway, which has been developed as a therapeutic target [502, 503], the PI3K/AKT/mTOR signaling pathway also plays a crucial role in cell survival and metabolism