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The Glutaminase-1 Inhibitor 968 Enhances Dihydroartemisinin-Mediated Antitumor Efficacy in Hepatocellular Carcinoma Cells

Consequently, inhibition of SLC7A11 by TP53 reduces glutathione synthesis, leading to lipid peroxide accumulation and inducing ferroptosis (98)

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Recently published results from The Selenium and Vitamin E Cancer Prevention Trial (SELECT) showed that Se supplementation (200 g/d), alone or with vitamin E for a period between 7 and 12 years, did not prevent diseases such as prostate, lung or colon cancers and there were no significant differences in cardiovascular events or diabetes between treatment groups in men ( Reference Lippman, Klein and Goodman 17 )