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TGF- Pathway Activation: The peptide enhances TGF- growth factor activity, stimulates fibroblast collagen synthesis, and promotes extracellular matrix production

Reviewing the team's patent and related documents at Talpos's request, Anna Mapp, the Edwin Vedejs Collegiate Professor of Chemistry at the University of Michigan, and also the President of the American Peptide Society, questioned the limited detail available and the absence of a published sequence for the peptide's parent protein, an omission she noted makes the original work impossible to reproduce

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On the gastrointestinal front, literature has described mucosal barrier protection via modulation of endogenous prostaglandin (PGE2) and heat shock proteins (HSP70/90)