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At the imaging level, metabolic imaging modalities such as positron emission tomography (PET), functional magnetic resonance imaging (fMRI), and emerging techniques like magnetic resonance spectroscopic imaging (MRSI) are being employed for non-invasive assessment of tumor metabolic activity and mitochondrial function [141, 142]

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Another example comes from broccoli: BrDEVs activated AMPK in dendritic cells within gut-associated lymphoid tissue, leading to diminished inflammatory signaling and marked improvement of colitis in mice [159]