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Tolerance has not been observed in clinical use

doi: 10.3389/fimmu.2019.00760 Received 24 October 2018 Accepted 21 March 2019 Published 24 April 2019 Volume 10 - 2019 Edited by Nurit Hollander, Tel Aviv University, Israel Reviewed by Alessandra Romano, Universit degli Studi di Catania, Italy

Nicotinamide N-methyltransferase (NNMT): a novel therapeutic target for metabolic syndrome Review article explaining why NNMT is studied as a metabolic target

They compared a target of 4.0 g/day against typical European intakes which range from 4.2 to 8.6 g/day in adults and believed 4.0 g/day to be a practical amount