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the soluble viral proteins serve as receptors as they bind to all cell surfaces, assuring unimpeded viral access and entry to new, uninfected cells

10.1085/jgp.200409040 27 BuelowB.SongY.ScharenbergA

This can cause mutations, malfunctions in cellular signaling pathways, and can initiate programmed cell death (apoptosis), contributing to chronic traumatic encephalopathy (CTE) neurodegeneration and other diseases [26,27]

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Regulation of Heme Biosynthesis Although heme is synthesized in virtually all tissues, the principal sites of synthesis are erythroid cells (85%) and hepatocytes