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The disulphide bond-containing loop structure may require slightly longer to fully dissolve than linear peptides

Lundgren, P

Elevated oxidative stress fosters the proliferation and hypertrophy of vascular smooth muscle cells, as well as collagen deposition, culminating in vascular medial thickening and constriction

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heterocycle or heterocyclic ring, as used herein except where noted, represents a stable 5- to 7-membered monocyclic-, or stable 7- to 11-membered bicyclic heterocyclic ring system, any ring of which may be saturated or unsaturated, and which consists of carbon atoms and from one to three heteroatoms selected from the group consisting of N, O and S, and wherein the nitrogen and sulfur heteroatoms may optionally be oxidized, and the nitrogen heteroatom may optionally be quaternized, and including any bicyclic group in which any of the above-defined heterocyclic rings is fused to a benzene ring

doi: 10.1111/jpi.12987, 27